A breakthrough discovery by Australian scientists is offering hope for children suffering from a rare and deadly brain tumor.
\nResearchers studying immunotherapy for inoperable cancers at the Walter and Eliza Hall Medical Research Institute in Melbourne say the treatment is effective at treating Diffuse Intrinsic Pontine Glioma (DIPG).
\nDIPG is an aggressive type of brain tumor that affects 20 children in Australia every year.
\nIt impacts the part of the brain responsible for vital functions like breathing, swallowing and movement – meaning it cannot be surgically removed.
\nAggressive cancer affects children between the ages of about five to seven and has previously been untreatable, with patients unlikely to survive a year after diagnosis.
\nResearchers have now discovered a new form of immunotherapy treatment, called CAR T therapy.
\nHead researcher, Associate Professor Misty Jenkins, says it offers hope for the devastating illness by boosting a patient’s existing immune cells.
\nCAR T cell therapy isolates a patient’s immune cells, engineering them to become “super killer cells” and then re-infusing them into the patient to fight the cancer.
\nIt trains the body to fight the cancer with its own cells, which means if the cancer returns, the cells will have a memory of their previous battles.
\n“These genetically modified white blood cells act as a ‘living drug’, which means the patient will retain a living memory in their body of the anti-tumor response that may also work to kill the tumor again if it ever returns,” she said.
\n“The way these cells can completely eliminate the tumors and persist in the body into the future is what is so exciting about CAR T cell therapy, and why immunotherapy is the future of precision medicine,” she said.
\nThe treatment involves CAR T cells that recognize a cancer-specific protein called HER2.
\nOnce in the brain, the CAR T cells recognize this protein and signal the T cells to kill the tumor cells.
\nUnlike radiation, which kills cancerous as well as healthy brain tissue, CAR T cell therapy uses a patient’s own immune cells and engineers them to recognize and kill the tumor.
\n“CAR T cells offer a possibility of cure, with no long-term side effects,” Prof Jenkins said.
\nThe study’s preclinical models showed the use of CAR T cell therapy had effectively eliminated the DIPG tumors, with the research published in the open access journal Neuro-Oncology Advances.
\nThe researchers said the finding lays the groundwork for thousands more potential therapies to combat DIPG.
\nThe study shows the treatment is safe for children, with hopes it will be available in a clinical setting soon.<\/p>\n","protected":false},"excerpt":{"rendered":"
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